Fig. 8.

Plk1 expression in human breast cancers. a Plk1 expression relative to TBP (log2) in genome-doubled (GD) and non-genome-doubled (nGD) breast cancers from the TCGA. p = 4.62e-09, t-test. b Plk1 expression in breast cancers with and without TP53 mutations. The association between GD and Plk1 expression is significant in TP53 wt tumors. p = 3.37e-06, t-test. c Survival analysis of breast cancer (BRCA) patients with low Plk1 expression (bottom quartile) and those with higher Plk1 expression (remaining quartile) p = 0.0099; hazard ratio (HR), 0.59; 95% confidence interval (CI), 0.40–0.89