Table 2.
Invasive ovarian cancer risk when first-degree relatives were diagnosed with other cancers.
| Cancer site | Patients with 1 FDR | Patients with ≥ 2 FDRs | P-trend | ||||||
|---|---|---|---|---|---|---|---|---|---|
| N | RR | 95%CI | Power (%) RR = 1.2 | N | RR | 95%CI | Power (%) RR = 1.4 | ||
| Ovary | 467 | 2.42 | 2.21–2.66 | 46.6 | 20 | 11.36 | 7.33–17.62 | 8.2 | <0.0001 |
| Upper aerodigestive tract | 239 | 1.08 | 0.95–1.23 | 52.7 | 4 | 1.46 | 0.55–3.90 | 9.1 | 0.1887 |
| Esophagus | 70 | 0.94 | 0.74–1.19 | 22.8 | 0 | — | — | — | 0.6042 |
| Stomach | 349 | 1.08 | 0.97–1.2 | 56.4 | 3 | 0.57 | 0.18–1.76 | 10.5 | 0.2887 |
| Small intestine | 41 | 1.02 | 0.75–1.38 | 16.3 | 1 | 4.07 | 0.57–28.93 | 37.7 | 0.7269 |
| Colorectum | 1009 | 1.06 | 1.00–1.13 | 96.7 | 58 | 1.16 | 0.89–1.50 | 37.7 | 0.0377 |
| Colon | 659 | 1.04 | 0.96–1.13 | 88.3 | 28 | 1.33 | 0.92–1.92 | 22.0 | 0.141 |
| Rectum | 395 | 1.07 | 0.97–1.19 | 69.7 | 10 | 1.48 | 0.80–2.76 | 12.3 | 0.0974 |
| Liver | 277 | 1.20 | 1.06–1.35 | 48.9 | 4 | 1.64 | 0.62–4.38 | 8.6 | 0.0024 |
| Pancreas | 271 | 1.14 | 1.01–1.28 | 50.4 | 2 | 0.70 | 0.18–2.80 | 9.1 | 0.0595 |
| Lung | 655 | 1.05 | 0.97–1.14 | 89.6 | 27 | 1.04 | 0.71–1.52 | 26.3 | 0.2382 |
| Breast | 1243 | 1.20 | 1.14–1.28 | 99.2 | 88 | 1.47 | 1.20–1.82 | 43.8 | <0.0001 |
| Cervix | 184 | 1.14 | 0.98–1.32 | 45.1 | 0 | — | — | — | 0.0862 |
| Endometrium | 317 | 1.27 | 1.14–1.42 | 54.4 | 4 | 1.40 | 0.53–3.73 | 9.0 | <0.0001 |
| Other female genitals | 39 | 0.94 | 0.69–1.29 | 15.0 | 0 | — | — | — | 0.7144 |
| Prostate | 1320 | 1.02 | 0.96–1.08 | 99.6 | 121 | 1.14 | 0.95–1.36 | 56.2 | 0.2174 |
| Testis | 35 | 1.20 | 0.86–1.68 | 23.8 | 1 | 4.37 | 0.62–31.03 | 6.7 | 0.1904 |
| Other male genitals | 30 | 1.74 | 1.21–2.49 | 10.4 | 0 | — | — | — | 0.0056 |
| Kidney | 276 | 1.08 | 0.96–1.22 | 56.2 | 3 | 0.89 | 0.29–2.75 | 9.6 | 0.2458 |
| Bladder | 403 | 0.96 | 0.87–1.06 | 75.5 | 14 | 1.57 | 0.93–2.66 | 13.7 | 0.8195 |
| Melanoma | 339 | 1.12 | 1.00–1.25 | 78.4 | 8 | 1.02 | 0.51–2.04 | 16.1 | 0.0573 |
| Skin | 387 | 0.98 | 0.88–1.08 | 72.4 | 12 | 1.20 | 0.68–2.11 | 14.8 | 0.8309 |
| Nervous system | 279 | 1.08 | 0.96–1.22 | 68.4 | 2 | 0.49 | 0.12–1.97 | 11.3 | 0.2972 |
| Thyroid gland | 75 | 1.04 | 0.83–1.31 | 29.0 | 0 | — | — | — | 0.7147 |
| Endocrine glands | 148 | 0.97 | 0.83–1.14 | 45.5 | 1 | 0.72 | 0.10–5.10 | 8.2 | 0.6948 |
| Connective tissue | 61 | 1.06 | 0.83–1.37 | 21.9 | 0 | — | — | — | 0.6436 |
| Non-Hodgkin lymphoma | 296 | 1.08 | 0.96–1.21 | 63.6 | 5 | 1.27 | 0.53–3.05 | 10.5 | 0.1882 |
| Hodgkin lymphoma | 52 | 1.28 | 0.97–1.68 | 20.0 | 0 | — | — | — | 0.0887 |
| Myeloma | 141 | 1.07 | 0.90–1.26 | 33.6 | 0 | — | — | — | 0.4464 |
| Leukemia | 250 | 0.99 | 0.87–1.12 | 60.7 | 2 | 0.50 | 0.13–2.01 | 10.4 | 0.6704 |
| CUP | 396 | 1.25 | 1.13–1.38 | 62.4 | 4 | 1.08 | 0.40–2.87 | 10.0 | <0.0001 |
| All cancersa | 4553 | 1.13 | 1.09–1.18 | 100.0 | 2589 | 1.29 | 1.23–1.36 | 100.0 | <0.0001 |
| All cancersb | 4340 | 1.10 | 1.06–1.15 | 100.0 | 2315 | 1.20 | 1.14–1.27 | 100.0 | <0.0001 |
FDR: first-degree relative; CUP: cancer of unknown primary.
Bolding, italic and underlining indicate that the 95% CI, 99% CI and 99.9% CI did not overlap with 1.00 respectively.
aall cancers include ovarian cancers and all other cancers.
ball cancers include all other cancers except ovarian cancer.