Table 3.
Other cancer risk when first-degree relatives were diagnosed with invasive ovarian cancer.
| Cancer site | Patients with 1 FDR | Patients with ≥2 FDRs | P-trend | ||||||
|---|---|---|---|---|---|---|---|---|---|
| N | RR | 95%CI | Power (%) RR = 1.2 | N | RR | 95%CI | Power (%) RR = 1.4 | ||
| Upper aerodigestive tract | 220 | 1.02 | 0.89–1.17 | 49.3% | 3 | 1.32 | 0.43–4.09 | 8.5 | 0.7011 |
| Esophagus | 52 | 0.76 | 0.58–1.00 | 20.5 | 1 | 1.29 | 0.18–9.16 | 6.6 | 0.0552 |
| Stomach | 134 | 1.11 | 0.94–1.32 | 31.3 | 3 | 2.29 | 0.74–7.10 | 7.4 | 0.1435 |
| Small intestine | 54 | 1.29 | 0.98–1.68 | 15.4 | 0 | — | — | — | 0.0793 |
| Colorectum | 884 | 1.07 | 1.00–1.15 | 95.1 | 6 | 0.70 | 0.31–1.56 | 13.4 | 0.0708 |
| Colon | 552 | 1.06 | 0.98–1.16 | 83.0 | 2 | 0.38 | 0.09–1.50 | 11.1 | 0.2651 |
| Rectum | 332 | 1.09 | 0.97–1.21 | 61.1 | 4 | 1.23 | 0.46–3.27 | 9.2 | 0.1264 |
| Liver | 167 | 1.20 | 1.03–1.40 | 35.2 | 4 | 2.66 | 1.00–7.10 | 7.6 | 0.0083 |
| Pancreas | 157 | 0.97 | 0.82–1.13 | 38.9 | 2 | 1.14 | 0.28–4.54 | 7.8 | 0.6918 |
| Lung | 634 | 1.10 | 1.01–1.19 | 85.4 | 5 | 0.80 | 0.33–1.92 | 11.4 | 0.0320 |
| Breast | 1981 | 1.24 | 1.19–1.30 | 99.9 | 30 | 2.13 | 1.49–3.05 | 19.5 | <0.0001 |
| Cervix | 165 | 1.08 | 0.92–1.26 | 43.3 | 2 | 1.65 | 0.41–6.61 | 7.9 | 0.3036 |
| Endometrium | 304 | 1.22 | 1.09–1.36 | 53.8 | 2 | 0.86 | 0.21–3.44 | 8.5 | 0.0014 |
| Uterusc | 6 | 2.63 | 1.16–5.95 | 5.6 | 0 | — | — | — | 0.0439 |
| Other female genitals | 27 | 0.89 | 0.61–1.30 | 13.0 | 0 | — | — | — | 0.5488 |
| Prostate | 1727 | 1.05 | 1.00–1.10 | 99.9 | 29 | 1.40 | 0.97–2.01 | 20.2 | 0.0149 |
| Testis | 117 | 1.15 | 0.95–1.37 | 38.0 | 0 | — | — | — | 0.1551 |
| Other male genitals | 22 | 1.16 | 0.76–1.77 | 10.1 | 0 | — | — | — | 0.5002 |
| Kidney | 226 | 1.10 | 0.96–1.25 | 48.4 | 5 | 2.30 | 0.96–5.53 | 8.4 | 0.0905 |
| Bladder | 333 | 0.99 | 0.89–1.10 | 64.7 | 4 | 1.07 | 0.40–2.85 | 9.5 | 0.8401 |
| Melanoma | 628 | 1.07 | 0.99–1.16 | 89.7 | 7 | 1.29 | 0.62–2.71 | 12.1 | 0.0645 |
| Skin | 333 | 1.06 | 0.95–1.18 | 62.5 | 2 | 0.62 | 0.16–2.49 | 9.3 | 0.3549 |
| Nervous system | 380 | 1.04 | 0.94–1.15 | 77.9 | 3 | 0.89 | 0.29–2.77 | 10.6 | 0.4900 |
| Thyroid gland | 111 | 1.11 | 0.92–1.34 | 31.7 | 1 | 1.18 | 0.17–8.35 | 7.4 | 0.2767 |
| Endocrine glands | 193 | 1.01 | 0.88–1.16 | 48.0 | 2 | 1.13 | 0.28–4.51 | 8.4 | 0.8776 |
| Connective tissue | 70 | 1.01 | 0.79–1.28 | 23.0 | 0 | — | — | — | 0.4857 |
| Non-Hodgkin lymphoma | 327 | 1.11 | 0.99–1.24 | 63.2 | 3 | 0.99 | 0.32–3.08 | 9.4 | 0.0751 |
| Hodgkin lymphoma | 71 | 1.20 | 0.95–1.51 | 25.0 | 2 | 4.11 | 1.03–16.46 | 7.0 | 0.0732 |
| Myeloma | 107 | 1.09 | 0.90–1.32 | 26.5 | 0 | — | — | — | 0.3765 |
| Leukemia | 248 | 0.98 | 0.86–1.11 | 63.4 | 3 | 1.22 | 0.39–3.79 | 9.4 | 0.8095 |
| CUP | 227 | 1.14 | 1.00–1.30 | 45.8 | 6 | 2.81 | 1.26–6.26 | 8.3 | 0.0157 |
| All cancersa | 10492 | 1.12 | 1.10–1.14 | 100.0 | 147 | 1.49 | 1.27–1.75 | 68.7 | <0.0001 |
| All cancersb | 10025 | 1.09 | 1.07–1.11 | 100.0 | 127 | 1.31 | 1.10–1.56 | 67.9 | <0.0001 |
FDR: first-degree relative; CUP: cancer of unknown primary.
Bolding, italic and underlining indicate that the 95% CI, 99% CI and 99.9% CI did not overlap with 1.00 respectively.
aall cancers include ovarian cancers and all other cancers.
ball cancers include all other cancers except ovarian cancer.
ccancer of other parts of uterus, including chorionepithelioma.