Table 1.
Biological functions of a subset of transmission stage specific parasite genes in our dataset.
| Protein description | Gene | Fold Change |
|---|---|---|
| Chaperone/Protein stability | ||
| Endoplasmin | PF3D7_1222300 | Day 6 and 8 |
| Heat shock 70 | PF3D7_0818900 | Day 4, 6, and 8 |
| Heat shock protein 70 | PF3D7_0917900 | Day 4, 6, and 8 |
| Heat shock protein 90 | PF3D7_0708400 | Day 4, 6, and 8 |
| Heat shock protein DNAJ homologue Pfj4 | PF3D7_1211400 | Day 8 |
| HSP40, subfamily A | PF3D7_1437900 | Day 6 and 8 |
| Hsp70/Hsp90 organizing protein | PF3D7_1434300 | Day 6 |
| co-chaperone p23 | PF3D7_1453700 | Day 4, 6, and 8 |
| T-complex protein 1 subunit ε | PF3D7_0320300 | Day 6 and 8 |
| T-complex protein 1 subunit β | PF3D7_0306800 | Day 6 and 8 |
| T-complex protein 1 subunit α | PF3D7_1132200 | Day 8 |
| T-complex protein 1 subunit δ | PF3D7_1357800 | Day 6 |
| Tubulin-specific chaperone a | PFA_0460c | Day 8 |
| Cytoskeleton | ||
| Actin I | PF3D7_1246200 | Day 4, 6, and 8 |
| Actin-depolymerizing factor 1 | PF3D7_0503400 | Day 8 |
| Tubulin β chain | PF3D7_1008700 | Day 8 |
| Nuclear polyadenylated RNA-binding protein NAB2 | PF3D7_0623100 | Day 8 |
| Cell Cycle | ||
| Cell division cycle protein 48 homologue | PF3D7_0619400 | Day 8 |
| Proliferating cell nuclear antigen 1 | PF3D7_1361900 | Day 4 and 8 |
| Chromatin | ||
| CCR4-NOT transcription complex subunit 5 | PF3D7_1006100 | Day 6 |
| DNA metabolism | ||
| ATP-dependent RNA helicase DDX5 | PF3D7_1445900 | Day 6 |
| RuvB-like helicase 2 | PF3D7_1106000 | Day 6 |
| RNA metabolism | ||
| Splicing factor 3B subunit 6 | PF3D7_1224900 | Day 6 |
| Splicing factor 1 | PF3D7_1321700 | Day 8 |
| serine/arginine-rich splicing factor 1 | PF3D7_0517300 | Day 6 |
| Histone H2A | PF3D7_0617800 | Day 2, 4, 6, and 8 |
| Histone H2A variant | PF3D7_0320900 | Day 4 and 8 |
| histone H2B variant | PF3D7_0714000 | Day 8 |
| histone H2B | PF3D7_1105100 | Day 4, 6, and 8 |
| Histone H3 | PF3D7_0610400 | Day 8 |
| Histone H3variant | PF3D7_0617900 | Day 2, 4, 6, and 8 |
| Histone H4 | PF3D7_1105000 | Day 4, 6, and 8 |
| Pseudouridine synthase | PF3D7_0219500 | Day 6 |
| ATP-dependent RNA helicase DDX23 | PF3D7_0518500 | Day 8 |
| Ubiquitin and proteasome | ||
| 26S protease regulatory subunit 4 | PF3D7_1008400 | Day 8 |
| 26S protease regulatory subunit 10B | PF3D7_1306400 | Day 4, 6, and 8 |
| 26S proteasome regulatory subunit RPN8 | PF3D7_0912900 | Day 4 and 6 |
| Beta3 proteasome subunit | PFA_0400c | Day 6 |
| Proteasome subunit β type-4 | PF3D7_0803800 | Day 8 |
| 26S proteasome regulatory subunit RPN10 | PF3D7_0807800 | Day 8 |
| Transcription | ||
| DNA-directed RNA polymerase 2 | PFA_0505c | Day 8 |
| Translation | ||
| 60S ribosomal protein L36 | PF3D7_1109900 | Day 6 and 8 |
| Elongation factor 1 (EF-1) | PF3D7_0319600 | Day 6 |
| Elongation factor 1-gamma | PF3D7_1338300 | Day 4, 6, and 8 |
| Elongation factor 2 | PF3D7_1451100 | Day 8 |
| Elongation factor-1 alpha | PF3D7_1357100 | Day 4 and 8 |
| Eukaryotic translation initiation factor 5a | PF3D7_1204300 | Day 4, 6 and 8 |
| Eukaryotic translation initiation factor 2 subunit alpha | PF3D7_0728000 | Day 8 |
| Eukaryotic translation initiation factor 3 subunit B | PF3D7_0517700 | Day 6 |
| Eukaryotic translation initiation factor 4 gamma | PF3D7_1312900 | Day 6 |
| Peptidyl-prolyl cis-trans isomerase | PF3D7_0322000 | Day 4, 6, and 8 |
| Protein disulfide isomerase | PF3D7_0827900 | Day 6 and 8 |
| 60S ribosomal protein L29 | PF3D7_1460300 | Day 6 |
| Translation initiation factor IF-2 | PF3D7_0607000 | Day 8 |
| Translation initiation factor SUI1 | PF3D7_1243600 | Day 4 and 8 |
| 40S ribosomal proteins | 19 | |
| 60S ribosomal proteins | 31 | |
| Protein processing | ||
| Peptide chain release factor subunit 1 | PF3D7_0212300 | Day 6 |
| Signal peptide peptidase | PF3D7_1457000 | Day 8 |
| Signal transduction | ||
| Casein kinase 2, alpha subunit | PF3D7_1108400 | Day 8 |
| GTPase-activating protein | PF3D7_0904000 | Day 4, 6, and 8 |
| Phosphoenolpyruvate carboxykinase | PF3D7_1342800 | Day 8 |
| Ras-related protein Rab-11a | PF3D7_1320600 | Day 6 |
| Ran-specific GTPase-activating protein 1 | PFD0950w | Day 4 and 6 |
| Serine/threonine protein phosphatase PP1 | PF3D7_1414400 | Day 8 |
| Metabolism | ||
| 1-cys peroxiredoxin | PF3D7_0802200 | Day 6 |
| 3-oxoacyl-(acyl-carrier protein) reductase | PF3D7_0922900 | Day 8 |
| protein DJ-1 | PF3D7_0627500 | Day 8 |
| Adenosine deaminase | PF3D7_1029600 | Day 8 |
| Adenosylhomocysteinase | PF3D7_0520900 | Day 8 |
| ATP synthase F1, alpha subunit | PF3D7_0217100 | Day 6 |
| Cytochrome c oxidase subunit 2 | PF3D7_1430900 | Day 8 |
| Dihydrofolate synthase/folylpolyglutamate synthase | PF3D7_1324800 | Day 2 |
| Fumarate hydratase | PF3D7_0927300 | Day 6 |
| NADP-specific glutamate dehydrogenase | PF3D7_1430700 | Day 8 |
| Glyceraldehyde-3-phosphate dehydrogenase | PF3D7_1462800 | Day 6 and 8 |
| Hypoxanthine phosphoribosyltransferase | PF10_0121 | Day 8 |
| L-lactate dehydrogenase | PF3D7_1324900 | Day 4, 6, and 8 |
| Malate dehydrogenase | PF3D7_0618500 | Day 8 |
| Phosphoethanolamine N-methyltransferase | PF3D7_1343000 | Day 8 |
| Phosphoglycerate mutase | PF3D7_1120100 | Day 6 |
| Purine nucleoside phosphorylase | PF3D7_0513300 | Day 4, 6, and 8 |
| Ribonucleoside-diphosphate reductase, large subunit | PF3D7_1437200 | Day 8 |
| S-adenosylmethionine decarboxylase-ornithine decarboxylase | PF3D7_1033100 | Day 4 and 6 |
| S-adenosylmethionine synthetase | PF3D7_0922200 | Day 4, 6, and 8 |
| Transketolase | PF3D7_0610800 | Day 6 |
| Cytochrome b-c1 complex subunit 7 | PF3D7_1012300 | Day 6 and 8 |
| Trafficking | ||
| Vesicle-associated membrane protein | PF3D7_1439800 | Day 8 |
| Nuclear transport factor 2 | PF3D7_1412300 | Day 8 |
| AP-1 complex subunit mu-1 | PF3D7_1311400 | Day 8 |
| Known Transporters | ||
| ADP/ATP transporter on adenylate translocase | PF3D7_1037300 | Day 6 and 8 |
| Major facilitator superfamily-related transporter | PF3D7_0914700 | Day 4, 6, and 8 |
| Surface/exported proteins | ||
| Asparagine-rich antigen | PF3D7_1110400 | Day 6 and 8 |
| Asparagine-rich antigen Pfa35-2 | PFA_0280w | Day 8 |
| Circumsporozoite (CS) protein | PF3D7_0304600 | Day 8 |
| Exported protein 1 | PF3D7_1121600 | Day 6 and 8 |
| CSP and TRAP-related protein | PF3D7_0315200 | Day 2 |
| PHF5-like protein | PF3D7_1018500 | Day 6 |
| Antigen UB05 | PF3D7_1038000 | Day 4 |
| Von Willebrand factor A domain-related protein (WARP) | PF3D7_0801300 | Day 2 |
| Erythrocyte membrane-associated antigen | PF3D7_0703500 | Day 6 and 8 |
| Miscellaneous (selected) | ||
| Conserved Plasmodium protein | PF3D7_0931300 | Day 6 and 8 |
| superoxide dismutase [Fe] | PF3D7_0814900 | Day 6 |
| Glideosome-associated protein 45 | PF3D7_1222700 | Day 8 |
| UVB-resistance protein UVR8 homologue | PF3D7_1137400 | Day 8 |
| Plasmodium repeat_MYXSPDY protein | PF10_0383 | Day 8 |