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. 2018 Aug 1;8:11526. doi: 10.1038/s41598-018-30032-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Tear proteome of hard and soft CL users. (a) Representative tear protein profiles of both types of CL wearers before (designated as A) and after (designated as B) CL renouncement compared to non-CL users (designated as CTRL) resolved in 1DE gel stained with colloidal blue. M: marker. (b) Venn diagram depicting overlaps of identified tear proteins in hard and soft CL users before and following lens renouncement compared to the control group. (c) Venn diagram showing overlaps of differentially expressed tear proteins in each CL subgroup before and after CL renouncement. (d) Heat map depicts the hierarchical clustering of the differentially expressed tear proteins in the hard and soft CL groups before (designated as A) and after (designated as B) CL renouncement compared to the CTRL.