Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Aug 1;8:11526. doi: 10.1038/s41598-018-30032-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Differential expression profiles of exemplary tear proteins of hard and soft CL users compared to CTRL. Box plots showing the different expression profiles of some of the significantly (p < 0.05) differentially expressed tear proteins in the two CL users that were restored to near-normal after renouncement comprising (a) A2M (b) PRIMPOL and (c) GC. Some proteins were not restored to near-normal or normal levels following the discontinuation of CL use, which comprised (d) CST5 in both CL users, (e) SFN and (f) GPI in the hard CL users. The expression profiles of (g) VTN and (h) S100P show exemplary proteins that were only up-regulated after hard CL renouncement and, (i) ANXA4 was exclusively down-regulated in the soft CL following renouncement. The y-axis represents the log₂ LFQ intensities of the proteins. Box represents the mean ± SE, whiskers represent mean ± 2*SD, plus sign (+) denotes the median and the horizontal line in the box denotes mean.