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. 2018 Aug 1;8:11528. doi: 10.1038/s41598-018-29972-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Metabolomic signature of Opa1^−/− vs Opa1^+/+ MEFs. (a) Unsupervised PCA score plot of Opa1^+/+ (blue rhombuses) and Opa1^−/− (red squares) MEF cell lines. There is a spontaneous separation on the t[2] axis related to genotype. (b) Supervised OPLS-DA score plot of Opa1^+/+ (blue rhombuses) and Opa1^−/− (red squares) MEF cell lines with the prediction of test samples (predicted Opa1^+/+ (light blue rhombuses) and predicted Opa1^−/− (light red squares)). The model, constructed with 31 molecules (shown in c), discriminates the Opa1 genotype on the t([1] + PS[1]) axis. (c) VIP plot showing the contribution of each metabolite to the model described in b. Molecules emphasized in black (VIP > 1) were considered the most significant molecules of the Opa1 signature.