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. 2018 Aug 1;8:11557. doi: 10.1038/s41598-018-29937-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Results of the voxel-wise analysis: effects of aging on ¹⁸F-FDG distribution. To assess the effects of aging and apolipoprotein E ε4 genotype, a voxel-wise analysis was performed on all participants using a two-way repeated-measures analysis of variance with two time points (baseline or second positron emission tomography scan) × two conditions (presence or absence of apolipoprotein E ε4 genotype). Sex and MMSE scores were specified as nuisance covariates. The aging effects on ¹⁸F-FDG distribution were significant at p < 0.05, familywise error rate-corrected. The significant clusters extended to the anterior cingulate cortex, posterior cingulate cortex/precuneus, and lateral parietal cortex. The hot scale represents the magnitude of the p and t values. ¹⁸F-FDG: fluorine-18-labeled fluorodeoxyglucose, R: right, L: left, MMSE: Mini-Mental State Examination.