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. 2018 Aug 1;8:11557. doi: 10.1038/s41598-018-29937-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Scatter plots depicting the relationship between ¹⁸F-FDG uptake and age at the baseline and second PET scans in all participants (n = 108). The blue and red circles represent ¹⁸F-FDG uptake in the ACC and PCC/PC, respectively. The results of the baseline scan (left) show a significant correlation in the ACC (r = 0.233, p = 0.016) but not the PCC/PC (r = 0.114, p = 0.240). The second PET scan (right) revealed significant correlations in the ACC (r = 0.274, p = 0.004) and PCC/PC (r = 0.303, p = 0.002). A solid line represents a simple regression line between the two variables. ¹⁸F-FDG: fluorine-18-labeled fluorodeoxyglucose, ACC: anterior cingulate cortex, PCC/PC: posterior cingulate cortex/precuneus, PET: positron emission tomography.