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. 2018 Aug 1;8:11557. doi: 10.1038/s41598-018-29937-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic model of the age-associated trajectories. The blue and red lines represent the age-associated decreases in ¹⁸F-FDG uptake in the ACC and PCC/PC, respectively. In the ACC (blue), ¹⁸F-FDG uptake decreased continuously over time. In the PCC/PC, ¹⁸F-FDG uptake was relatively stable before age 60–70 and then started to decease in an age-associated manner. ¹⁸F-FDG: fluorine-18-labeled fluorodeoxyglucose, ACC: anterior cingulate cortex, PCC/PC: posterior cingulate cortex/precuneus.