Fig. 1.

Fabrication of PLLA-b-PEG block copolymer crystalsomes. a Dissolution of the BCP in toluene; b emulsification at 95 °C; c quenching to 25 °C for crystallization. The driving force of this assembly process is confined PLLA crystallization at the toluene/water interface, leading to a ninefold PLLA chain conformation as shown in c. This confined crystallization process also leads to a 2.5 nm thick PLLA crystal layer, covered with a precisely controlled, uniform PEG brush layer (grafting density of 0.3 chain nm⁻²)