Fig. 5.

Dependence of BCC blood circulation on their crystallinity. a In vivo circulation of DiD-loaded BCCs crystallized for different times. b In vivo circulation performance among representative polymeric nanoparticles (PEO-b-PEE polymersomes⁴⁷, RBC-PLGA NP⁶, surface-modified PLGA-PEG NP⁴⁴, BCP micelles⁵⁶, and PRINT nanogels³⁰) with long blood circulation. A plot of relative intensities at 24 h vs. apparent half-lives, where relative symbol sizes represent relative hydrodynamic sizes/shapes and data are taken from the respective references. c BCC crystallinity and half-life variation with different crystallization times. d The correlation of circulation half-life and crystallinity of BCCs. Error bars in a, c represent mean ± s.d, n = 3–5