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. 2018 Jul 26;9:421. doi: 10.3389/fendo.2018.00421

Figure 1.

Figure 1

Effects of empagliflozin treatment on systolic blood pressure (SBP), and on circadian rhythm of SBP, in Otsuka Long Evans Tokushima Fatty (OLETF) rats. (A) 24-h SBP. (B) Average of 24-h SBP. (C) SBP in dark and light periods. (D) Differences between dark and light period in SBP. OLETF rats were treated with vehicle (vehicle, n = 7), 1% NaCl drinking water (high-salt, n = 5), or 1% NaCl drinking water and empagliflozin (high-salt + empagliflozin, n = 8), for 5 weeks. Values are mean ± SEM. ***P < 0.0001 vs. vehicle and high-salt + empagliflozin (one-way analysis of variance followed by Tukey's multiple comparison test), †P < 0.0001 vs. high-salt + empagliflozin dark period (2-way analysis), #P < 0.0001 vs. high-salt light period (t-test), *P < 0.05 vs. high-salt (t-test).