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. 2018 Jul 26;9:421. doi: 10.3389/fendo.2018.00421

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Copyright © 2018 Wan, Rahman, Hitomi and Nishiyama.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of empagliflozin treatment on low frequency (LF) of systolic blood pressure (SBP), and on circadian rhythm of LF of SBP, in Otsuka Long Evans Tokushima Fatty (OLETF) rats. (A) 24-h LF of SBP. (B) Average of 24-h LF of SBP. (C) LF of SBP in dark and light period. (D) Differences between dark and light period in LF of SBP. OLETF rats were treated with vehicle (vehicle, n = 7), 1% NaCl drinking water (high-salt, n = 5), or 1% NaCl drinking water and empagliflozin (high-salt + empagliflozin, n = 8), for 5 weeks. Values are mean ± SEM. †P < 0.001 vs. high-salt + empagliflozin dark period (2-way analysis), #P < 0.001 vs. high-salt light period (t-test), ^*P < 0.05 vs. vehicle (one-way analysis of variance followed by Tukey's multiple comparison test).