Figure 3.

MK-8931 treatment did not cause spine elimination. (A) Spine stability and turnover rates in vehicle and MK-8931 treated mice. Daily turnover rate significantly decreased at the end of inhibitor treatment. (B,C) MK-8931 treatment significantly decreased density of transient spines, whereas density of stable spines was not affected. Bonferroni post-hoc test: ns: p = 0.4926, *p < 0.05, ***p < 0.001, ****p < 0.0001 (two-way ANOVA between day 0–28). (D) Survival rate of newly gained spines was not affected by BACE1 inhibitor treatment. N = 5 animals per group, n = 10 dendrites per animal. Two-tailed Student’s t-test, t₍₈₎ = 0.9, p = 0.394. Data presented as mean ± SEM.