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. 2018 Jul 26;9:1683. doi: 10.3389/fimmu.2018.01683

Figure 1.

Figure 1

Comparison of the gene organization of salmonid IL2 genes with mammalian IL2 and other fish IL2 and IL2L genes. The black and white boxes represent non-coding and amino acid (aa) coding regions, respectively. The black bars represent introns. The sizes (bp) of the coding regions are numbered in the boxes. The gene organization of the salmonid IL2 genes was predicted using the Spidey program based on the sequence information from Table S2 and Figures S1–S9 in Supplementary Material. The human, cow, and rat IL2 gene organization was extracted from Ensemble genes ENSG00000109471, ENSBTAG00000020883, and ENSRNOG00000017348, respectively. Other fish IL2/IL2L genes were extracted from the NCBI genomic sequences NC_018903 (Fugu), CAAE01023259 (Tetraodon), and AANH01006550 (Stickleback). The aa sequence domains (signal peptide, helices A–D, AB, and CD loops) encoded by each exon are indicated above.