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. 2018 Jul 26;9:1683. doi: 10.3389/fimmu.2018.01683

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Copyright © 2018 Wang, Hu, Wangkahart, Liu, Wang, Zahran, Maisey, Liu, Xu, Imarai and Secombes.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Modulation of regulatory pathway gene expression by IL-2 isoforms in peripheral blood leukocytes (PBL). Freshly prepared PBL from four fish were stimulated with IL-2A, IL-2B, IL-2A + IL-2B, or with medium alone as control. The expression of TGFβ1A (A), TGFβ1B (B), IL10A (C), IL10B (D), FOXP3A (E) and FOXP3B (F) was quantified and presented as in Figure 8. Significant results of a paired samples T-test between the stimulated samples and time-matched controls are shown above the bars as *p ≤ 0.05, **p ≤ 0.01, and ***p ≤ 0.001. Different letters over the control bars indicate significant differences over time in the unstimulated cells (p ≤ 0.05). The expression levels in samples treated with IL-2A + IL-2B are higher than with IL-2A for IL10A and FOXP3A at 4 h, and IL10B at 24 h, and higher than with IL-2B for IL10B at 4 h (p ≤ 0.05).