Table 2.
Data on BM events [(a)symptomatic BM occurrence] and incidence of the included RCTs evaluating PCI.
| PCI |
No PCI |
||||||
|---|---|---|---|---|---|---|---|
| Study | Events | Total | Incidence (%) | Events | Total | Incidence (%) | Weight (%) |
| VALG | 7 | 136 | 5.1 | 16 | 145 | 11.0 | 10.5 |
| MDACC | 2 | 46 | 4.3 | 14 | 51 | 27.5 | 9.0 |
| RTOG 8403 | 8 | 93 | 8.6 | 18 | 94 | 19.1 | 12.2 |
| SWOG | 1 | 111 | 0.9 | 13 | 115 | 11.3 | 8.7 |
| RTOG 0214 | 13 | 163 | 8.0 | 32 | 177 | 18.1 | 20.9 |
| Li | 10 | 81 | 12.3 | 29 | 75 | 38.7 | 20.5 |
| NVALT-11 | 7 | 87 | 8.0 | 27 | 88 | 30.7 | 18.3 |
| Total | 48 | 717 | 149 | 745 | |||
PCI, prophylactic cranial irradiation; BM, brain metastasis; RCTs, randomized controlled trials.