Table 3.
RCTs evaluating PCI-related toxicity and QoL in NSCLC.
| Study | PCI dose (Gy/fraction) | Neuropsychological test | Evaluation after PCI | Impairment after PCI | QoL instruments and results |
|---|---|---|---|---|---|
| MDACC | 30/10 | Not reported | Not reported | Acute toxicity: one patient developed transient memory loss for 2.5 weeks | Not reported |
| Late toxicity: none | |||||
| RTOG 8403 | 30/10 | Neurological physical examinations | Intervals of 3 months | Acute toxicity: epilation and skin reactions | Not reported |
| Late toxicity: none | |||||
| RTOG 0214 | 30/15 | MMSE ADLS HVLT |
At 3, 6, 12, 18, 24, 30, 36, and 48 months, and then yearly | Acute toxicity: constitutional (grade 1 and 2), gastrointestinal (grade 1), dermatologic (grade 2), hematologic (grade 3), fatigue (grade 3), dyspnea (grade 3), ataxia (grade 3), depression (grade 3 and 4) | EORTC QLQ-C30 and EORTC QLQ-BN20 |
| Late toxicity: dyspnea, syncope, weakness, fatigue (all grade 3) | Global health status/QoL was similar between both arms | ||||
| Li | 30/10 | CTC-AE RTOG/EORTC-LRMSS |
First 2 years every 3 months, every 6 months thereafter | Acute toxicity: headache (grade 1, 2, and 3), nausea or vomiting (grade 1 and 2), fatigue (grade 1, 2, and 3), skin toxicity (grade 1 and 2), insomnia (grade 2) | FACT-L questionnaire |
| Late toxicity: mild, moderate, and severe headache, slight or great lethargy, skin atrophy, fatigue | No significant differences were noted in deterioration rate for QoL and symptoms between the two groups | ||||
| NVALT-11 | 36/18 30/12 30/10 |
CTC-AE | 4 weeks, 3, 6, 12, 24, and 36 months | Memory impairment (grade 1 and 2), cognitive disturbance (grade 1 and 2), alopecia, fatigue, headache | EORTC QLQ-C30 EORTC QLQ-BN20 EuroQol 5D Results not reported |
PCI, prophylactic cranial irradiation; QoL, quality of life; MMSE, Mini Mental Status Exam; ADLS, Activities of Daily Living Scale; HVLT, Hopkins Verbal Learning Test; CTC-AE, Common Terminology Criteria Adverse Events; RTOG/EORTC-LRMSS, RTOG/ERTOC late radiation morbidity scoring schema; EORTC QLQ-C30, EORTC quality of life questionnaire-C30; EORTC QLQ-BN20, EORTC quality of life questionnaire-BN20; FACT-L questionnaire, Functional Assessment of Cancer Therapy-Lung questionnaire; NSCLC, non-small cell lung cancer; RCTs, randomized controlled trials.