Table 3.
Tissues Sampled at Necropsy
| Tissues Collected for Histopathology | ||
|---|---|---|
| Adrenal gland, left | large intestine, colon | pancreas |
| Adrenal gland, right | liver, caudate lobe | small intestine, duodenum |
| Aorta (thoracic and abdominal) | liver, left lobe | small intestine, jejunum |
| Ascending aorta (proximal) | liver, middle lobe | spinal cord |
| Bone marrow, femur | liver, right lobe | spleen |
| Brain, cerebellum | lung, left | stomach |
| Brain, cerebrum | lung, right | testicle, left |
| Dorsal root gangliaa | lymph node, axillary | testicle, right |
| Esophagus | lymph node, inguinal | thymus |
| Eyes (left) | lymph node, mesenteric | thyroid gland (with parathyroid) |
| Gall bladder | lymph node, popliteal | trachea |
| Heart | muscle, quadriceps femoris | trigeminal nerve gangliona |
| Kidney, left | ovary, left | gross lesions (if any) |
| Kidney, right | ovary, right | injection site |
| Tissues Collected for Biodistribution | ||
| Bone marrow, femur | kidney, right | ovary, left |
| Brain, cerebellum | liver, caudate lobe | ovary, right |
| Brain, frontal cortex | liver, left lobe | spinal cord, cervical |
| Brain, hippocampus | liver, middle lobe | spinal cord, lumbar |
| Brain, medulla | liver, right lobe | spinal cord, thoracic |
| Brain, occipital cortex | lung, left | spleen |
| Brain, parietal cortex | lung, right | testicle, left |
| Brain, temporal cortex | lymph node, axillary | testicle, right |
| Dorsal root gangliaa | lymph node, inguinal | thyroid gland (with parathyroid) |
| Eyes (right) | lymph node, mesenteric | trigeminal nerve gangliona |
| Heart | lymph node, popliteal | gross lesions (if any) |
| Kidney, left | – | – |
| Tissues Collected for Lymphocyte Isolation | ||
| Spleen | bone marrow | – |
a
DRG and trigeminal nerve ganglia were not sampled in the original study RGX151002p; RGX160822p was designed to further investigate CNS and PNS findings from RGX151002p. Therefore, all of the tissues listed here were sampled, but only the target CNS and PNS tissues were processed in the later study.