Table 3.
Serum Antibody Titers to AAVrh74 Capsid at Baseline and after rAAVrh74.MCK.GALGT2 Treatment
| Time |
Baseline |
1 Month |
2 Months |
3 Months |
||||
|---|---|---|---|---|---|---|---|---|
| Subject | 07D147 | 04C034 | 07D147 | 04C034 | 07D147 | 04C034 | 07D147 | 04C034 |
| Last point serum dilution point (positive) | <1:50 | <1:50 | 1:6,400 | 1:12,800 | 1:51,200 | 1:12,800 | 1:51,200 | 1:25,600 |
| Ratio of sample to background (>2 is positive) | 0.4 | 1.4 | 2.9 | 3.0 | 2.8 | 2.4 | 2.0 | 2.0 |
| First serum dilution point (negative) | NA | NA | 1:12,800 | 1:25,600 | 1:102,400 | 1:25,600 | 1:102,400 | 1:51,200 |
| Ratio of sample to background (negative) | NA | NA | 1.6 | 1.5 | 1.3 | 1.5 | 0.8 | 1.1 |
| Positive control (ratio of sample to background) | 14.7 | 21.0 | 10.3 | 10.3 | 7.7 | 10.9 | 8.0 | 8.4 |
| Negative control (ratio of sample to background) | 0.2 | 0.5 | 0.3 | 0.3 | 0.2 | 0.2 | 0.2 | 0.4 |
NA, not applicable.