Fig. 1.

WM tissue segmentation separately marked in 3D-FLAIR axial reformat (A). Multiple T2-hyperintense lesions were selected by semi-automated segmentation and manually edited (B). DAWM tissue volumes characterized by intermediate T2 signal were retrieved by selectively applying an increased threshold around T2 lesion (C). Finally the subtraction of T2 lesion and DAWM volume from total WM segmentation resulted into NAWM (D). All regions were 3D-resolved binary maps.