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Proposed catalytic mechanisms for iAANAT. (A) Mechanism demonstrating a general base functioning to deprotonate the positively charged amine yielding a zwitterionic tetrahedral intermediate. Subsequent protonation and release of the CoA-SH product yields the final fatty acylamide product. (B) Mechanism demonstrating both a general base and general acid functioning in intermediate collapse and release of the CoA-SH and fatty acylamide products.
