Figure 2.

Associations between Inferior Longitudinal Fasciculus microstructural changes and Parkinson's disease symptomatology. Data suggests that systemic inflammation can lead to ILF disintegrity, exhibited by higher mean diffusivity (MD) and lower fractional anisotropy (FA), and thereby contributes to PD symptoms such as a range of cognitive impairments, depression, olfaction dysfunction, facial emotion recognition deficit, color discrimination deficit, and tremor genesis. ILF also has been inconsistently shown to play a role in sleep disorders (like RBD), impulsive compulsive behaviors, and freezing of gate, which needs to be further investigated.