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. 2018 Jun 26;9(7):320. doi: 10.3390/genes9070320
siNFκB MCF-7
Fold Change Gene Symbol Description GO Biological Process GO Molecular Function
1.84 NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20 kDa (NADH-coenzyme Q reductase) mitochondrial electron transport; oxidation-reduction process NADH dehydrogenase activity; oxidoreductase activity
1.75 PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) prostaglandin biosynthetic process; fatty acid metabolic process peroxidase activity; lipid binding; heme binding; metal ion binding; dioxygenase activity; oxidoreductase activity
1.67 PLCD1 phospholipase C, delta 1 phospholipid metabolic process; inositol phosphate metabolic process calcium ion binding; phosphoric diester hydrolase activity; phosphatidylserine binding
1.61 CYB561A3 cytochrome b561 family, member A3 oxidation-reduction process protein binding; oxidoreductase activity; metal ion binding
1.6 PLA2G1B phospholipase A2, group IB (pancreas) activation of MAPK activity; fatty acid biosynthetic process phospholipase activity; receptor binding; calcium ion binding; hydrolase activity; metal ion binding
1.59 PDE3B phosphodiesterase 3B, cGMP-inhibited cAMP catabolic process; glucose homeostasis metal ion binding; phosphoric diester hydrolase activity
1.57 FTHL17 ferritin, heavy polypeptide-like 17 iron ion transport ferric iron binding; metal ion binding
1.57 LPO lactoperoxidase response to oxidative stress; hydrogen peroxide catabolic process; oxidation-reduction process heme binding; metal ion binding; peroxidase activity; oxidoreductase activity
1.57 TXNP6 thioredoxin pseudogene 6 response to oxidative stress
1.56 PLA2G15 phospholipase A2, group XV phospholipid metabolic process phospholipase activity; hydrolase activity
1.54 PLD6 phospholipase D family, member 6 phospholipid metabolic process; nucleic acid phosphodiester bond hydrolysis endoribonuclease activity; metal ion binding; endonuclease activity; hydrolase activity
1.52 MSRB1 methionine sulfoxide reductase B1 response to oxidative stress; protein repair; oxidation-reduction process zinc ion binding; oxidoreductase activity; metal ion binding
1.51 PEX16 peroxisomal biogenesis factor 16 protein targeting to peroxisome; peroxisome organization protein binding
1.5 PRDX5 peroxiredoxin 5 response to oxidative stress; inflammatory response; apoptotic process thioredoxin peroxidase activity; antioxidant activity; receptor binding; oxidoreductase activity
1.5 TP53RK TP53 regulating kinase tRNA modification; protein phosphorylation; p53 binding protein serine/threonine kinase activity; ATP binding; hydrolase activity; nucleotide binding
−1.51 CYB5R4 cytochrome b5 reductase 4 superoxide metabolic process; glucose homeostasis; oxidation-reduction process; NADP metabolic process oxidoreductase activity; heme binding; metal ion binding
−1.53 PEX1 peroxisomal biogenesis factor 1 protein targeting to peroxisome; peroxisome organization protein binding; ATP binding; nucleotide binding
−1.54 DECR1 2,4-dienoyl CoA reductase 1, mitochondrial fatty acid metabolic process; oxidation-reduction process NADPH binding; oxidoreductase activity
−1.56 TXNDC9 thioredoxin domain containing 9 cell redox homeostasis; biological process protein binding
−1.61 SEPP1 selenoprotein P, plasma, 1 selenium compound metabolic process; response to oxidative stress selenium binding
−1.62 OXR1 oxidation resistance 1 response to oxidative stress; oxidation-reduction process protein binding; oxidoreductase activity
−1.63 TMX1 thioredoxin-related transmembrane protein 1 protein folding; cell redox homeostasis; oxidation-reduction process disulfide oxidoreductase activity
−1.64 PLCB4 phospholipase C, beta 4 lipid metabolic process calcium ion binding; phosphoric diester hydrolase activity; phospholipase C activity
−1.81 CYCS cytochrome c, somatic mitochondrial electron transport; apoptotic process iron ion binding; electron transfer activity; heme binding
−2.1 PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha glucose metabolic process; 1-phosphatidylinositol-3-kinase activity transferase activity; protein serine/threonine kinase activity; ATP binding
−2.19 MDM1 Mdm1 nuclear protein homolog (mouse) p53 binding protein; regulation of centriole replication protein binding
−2.76 ATM ATM serine/threonine kinase; nuclear protein, ataxia-telangiectasia locus DNA repair; telomere maintenance transferase activity; DNA binding; protein serine/threonine kinase activity
−2.81 PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha phosphatidylinositol biosynthetic process phosphotransferase activity; ATP binding
−2.85 ATR ATR serine/threonine kinase DNA repair; cell cycle; DNA damage checkpoint transferase activity; DNA binding; protein serine/threonine kinase activity
−3.04 NUDT12 nudix (nucleoside diphosphate linked moiety X)-type motif 12 NADP catabolic process metal ion binding; hydrolase activity
−3.18 CYP4F30P cytochrome P450, family 4, subfamily F, polypeptide 30 oxidation-reduction process oxidoreductase activity
−3.57 PYROXD1 pyridine nucleotide-disulfide oxidoreductase domain 1 oxidation-reduction process protein binding; oxidoreductase activity
−3.82 BRCA2 breast cancer 2, early onset double-strand break repair via homologous recombination; DNA synthesis involved in DNA repair protease binding; histone acetyltransferase activity; protein binding; H3 histone acetyltransferase activity; H4 histone acetyltransferase activity; gamma-tubulin binding; DNA binding
−3.88 ATRX alpha thalassemia/mental retardation syndrome X-linked DNA repair; nucleosome assembly chromatin binding; helicase activity; DNA binding; DNA helicase activity; helicase activity