1.84 |
NDUFS7 |
NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20 kDa (NADH-coenzyme Q reductase) |
mitochondrial electron transport; oxidation-reduction process |
NADH dehydrogenase activity; oxidoreductase activity |
1.75 |
PTGS1 |
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) |
prostaglandin biosynthetic process; fatty acid metabolic process |
peroxidase activity; lipid binding; heme binding; metal ion binding; dioxygenase activity; oxidoreductase activity |
1.67 |
PLCD1 |
phospholipase C, delta 1 |
phospholipid metabolic process; inositol phosphate metabolic process |
calcium ion binding; phosphoric diester hydrolase activity; phosphatidylserine binding |
1.61 |
CYB561A3 |
cytochrome b561 family, member A3 |
oxidation-reduction process |
protein binding; oxidoreductase activity; metal ion binding |
1.6 |
PLA2G1B |
phospholipase A2, group IB (pancreas) |
activation of MAPK activity; fatty acid biosynthetic process |
phospholipase activity; receptor binding; calcium ion binding; hydrolase activity; metal ion binding |
1.59 |
PDE3B |
phosphodiesterase 3B, cGMP-inhibited |
cAMP catabolic process; glucose homeostasis |
metal ion binding; phosphoric diester hydrolase activity |
1.57 |
FTHL17 |
ferritin, heavy polypeptide-like 17 |
iron ion transport |
ferric iron binding; metal ion binding |
1.57 |
LPO |
lactoperoxidase |
response to oxidative stress; hydrogen peroxide catabolic process; oxidation-reduction process |
heme binding; metal ion binding; peroxidase activity; oxidoreductase activity |
1.57 |
TXNP6 |
thioredoxin pseudogene 6 |
response to oxidative stress |
1.56 |
PLA2G15 |
phospholipase A2, group XV |
phospholipid metabolic process |
phospholipase activity; hydrolase activity |
1.54 |
PLD6 |
phospholipase D family, member 6 |
phospholipid metabolic process; nucleic acid phosphodiester bond hydrolysis |
endoribonuclease activity; metal ion binding; endonuclease activity; hydrolase activity |
1.52 |
MSRB1 |
methionine sulfoxide reductase B1 |
response to oxidative stress; protein repair; oxidation-reduction process |
zinc ion binding; oxidoreductase activity; metal ion binding |
1.51 |
PEX16 |
peroxisomal biogenesis factor 16 |
protein targeting to peroxisome; peroxisome organization |
protein binding |
1.5 |
PRDX5 |
peroxiredoxin 5 |
response to oxidative stress; inflammatory response; apoptotic process |
thioredoxin peroxidase activity; antioxidant activity; receptor binding; oxidoreductase activity |
1.5 |
TP53RK |
TP53 regulating kinase |
tRNA modification; protein phosphorylation; p53 binding |
protein serine/threonine kinase activity; ATP binding; hydrolase activity; nucleotide binding |
−1.51 |
CYB5R4 |
cytochrome b5 reductase 4 |
superoxide metabolic process; glucose homeostasis; oxidation-reduction process; NADP metabolic process |
oxidoreductase activity; heme binding; metal ion binding |
−1.53 |
PEX1 |
peroxisomal biogenesis factor 1 |
protein targeting to peroxisome; peroxisome organization |
protein binding; ATP binding; nucleotide binding |
−1.54 |
DECR1 |
2,4-dienoyl CoA reductase 1, mitochondrial |
fatty acid metabolic process; oxidation-reduction process |
NADPH binding; oxidoreductase activity |
−1.56 |
TXNDC9 |
thioredoxin domain containing 9 |
cell redox homeostasis; biological process |
protein binding |
−1.61 |
SEPP1 |
selenoprotein P, plasma, 1 |
selenium compound metabolic process; response to oxidative stress |
selenium binding |
−1.62 |
OXR1 |
oxidation resistance 1 |
response to oxidative stress; oxidation-reduction process |
protein binding; oxidoreductase activity |
−1.63 |
TMX1 |
thioredoxin-related transmembrane protein 1 |
protein folding; cell redox homeostasis; oxidation-reduction process |
disulfide oxidoreductase activity |
−1.64 |
PLCB4 |
phospholipase C, beta 4 |
lipid metabolic process |
calcium ion binding; phosphoric diester hydrolase activity; phospholipase C activity |
−1.81 |
CYCS |
cytochrome c, somatic |
mitochondrial electron transport; apoptotic process |
iron ion binding; electron transfer activity; heme binding |
−2.1 |
PIK3CA |
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
glucose metabolic process; 1-phosphatidylinositol-3-kinase activity |
transferase activity; protein serine/threonine kinase activity; ATP binding |
−2.19 |
MDM1 |
Mdm1 nuclear protein homolog (mouse) |
p53 binding protein; regulation of centriole replication |
protein binding |
−2.76 |
ATM |
ATM serine/threonine kinase; nuclear protein, ataxia-telangiectasia locus |
DNA repair; telomere maintenance |
transferase activity; DNA binding; protein serine/threonine kinase activity |
−2.81 |
PIK3C2A |
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha |
phosphatidylinositol biosynthetic process |
phosphotransferase activity; ATP binding |
−2.85 |
ATR |
ATR serine/threonine kinase |
DNA repair; cell cycle; DNA damage checkpoint |
transferase activity; DNA binding; protein serine/threonine kinase activity |
−3.04 |
NUDT12 |
nudix (nucleoside diphosphate linked moiety X)-type motif 12 |
NADP catabolic process |
metal ion binding; hydrolase activity |
−3.18 |
CYP4F30P |
cytochrome P450, family 4, subfamily F, polypeptide 30 |
oxidation-reduction process |
oxidoreductase activity |
−3.57 |
PYROXD1 |
pyridine nucleotide-disulfide oxidoreductase domain 1 |
oxidation-reduction process |
protein binding; oxidoreductase activity |
−3.82 |
BRCA2 |
breast cancer 2, early onset |
double-strand break repair via homologous recombination; DNA synthesis involved in DNA repair |
protease binding; histone acetyltransferase activity; protein binding; H3 histone acetyltransferase activity; H4 histone acetyltransferase activity; gamma-tubulin binding; DNA binding |
−3.88 |
ATRX |
alpha thalassemia/mental retardation syndrome X-linked |
DNA repair; nucleosome assembly |
chromatin binding; helicase activity; DNA binding; DNA helicase activity; helicase activity |