Table 4.
Summary of IMPDH2 and mouse splenocyte proliferation inhibition assays for 1–11.
| Compound | IC50 (µM) b Inosine-5′-Monophosphate Dehydrogenase (IMPDH2) | IC50 (µM) b Mouse Splenocyte Proliferation | Docking Score c |
|---|---|---|---|
| 1 | 0.92 ± 0.08 | 4.21 ± 0.20 | 8.04 |
| 2 | 0.95 ± 0.09 | 1.23 ± 0.07 | 8.21 |
| 3 | 0.84 ± 0.11 | 2.76 ± 0.13 | 7.83 |
| 4 | 3.27 ± 0.18 | 9.12 ± 0.38 | 7.12 |
| 5 | 24.68 ± 2.74 | >40 | 5.37 |
| 6 | 8.59 ± 0.43 | 19.65 ± 0.89 | 6.85 |
| 7 | 12.64 ± 1.86 | 24.58 ± 1.34 | 6.96 |
| 8 | 15.73 ± 1.65 | 30.56 ± 2.19 | 6.17 |
| 9 | 23.76 ± 3.54 | >40 | 5.46 |
| 10 | 17.52 ± 1.30 | >40 | 6.28 |
| MPA (11) a | 0.59 ± 0.08 | 0.96 ± 0.05 | 8.15 |
a MPA was selected as the positive control; b Data represent the mean ± SD of three triplicate experiments; c Interaction potential of compounds with target protein.