Figure 1.

Schematic representation of the transcriptional regulators of zinc homeostasis from Aspergillus fumigatus (ZafA), Cryptococcus gattii (CgZap1), Candida albicans (CaZap1) and Saccharomyces cerevisiae (ScZap1). Green boxes indicate canonical zinc finger (ZF) domains of the C2H2-type. Blue and orange boxes indicate ZFs of the CWCH2-type. These ZFs are typically arranged in pairs forming tandem CWCH2 motifs (tCWCH2). The ZF of the CWCH2-type that is presumably able to bind DNA is indicated as an orange box. Protein sequences were aligned taking as reference the ZF of the C2H2-type located towards the N-terminus in ZafA (i.e., ZF3).