Table 2.
Cell lines employed for the characterization of the recombinant viruses and BACs.
| Cell Line | Infecting Recombinant Virus | Displayed Receptor | Genetic Modification | Tissue/Cell Type | Ref. |
|---|---|---|---|---|---|
| Human cancer | |||||
| LNCaP | R-593, R-LM5 | Natural HSV receptors *, PSMA | none | hu prostate adenocarcinoma | [51] |
| MDA-MB-231 | R-LM5, R-611 | Natural HSV receptors *, EGFR | none | hu mammary adenocarcinoma | [52] |
| hGic-G7 | R-LM5 | Natural HSV receptors * | none | hu glioblastoma | [45] |
| hGic-G15 | R-613, R-LM5 | Natural HSV receptors *, EGFRvIII | none | hu glioblastoma | [45] |
| PC3-PIP-PSMA | R-593 | Natural HSV receptors *, PSMA | express hu PSMA | hu prostate adenocarcinoma | [53] |
| Rh4 | R-LM5 | Natural HSV receptors * | none | hu muscle rhabdomyosarcoma | [44] |
| SK-OV-3 | R-LM5, R-LM113, R-115, R-LM249, R-291, R-611 | Natural HSV receptors *, HER2, EGFR | none | hu ovary adenocarcinoma | [54] |
| U251** | R-LM5 | Natural HSV receptors *, EGFR | none | hu glioma | [55] |
| U251-EGFRvIII | R-613, R-615, R-613GLuc, R-615GLuc, R-LM5 | Natural HSV receptors *, EGFR, EGFRvIII | express hu EGFRvIII | hu glioma | This paper |
| Animal cell lines | |||||
| B16-HER2 | R-LM249, R-291 | HER2 | express hu HER2 | mu melanoma | [48] |
| CHO-EGFR | R-611 | EGFR | express hu EGFR | hamster ovary | [46] |
| J | none | none | wt HSV receptor negative | hamster kidney | [47] |
| J-EGFR | R-611 | EGFR | express hu EGFR | hamster kidney | This paper |
| J-EGFRvIII | R-613, R-615, R-613GLuc, R-615GLuc | EGFRvIII | express hu EGFRvIII | hamster kidney | This paper |
| J-HER2 | R-LM113, R-115, R-LM249, R-291 | HER2 | express hu HER2 | hamster kidney | [27] |
| J-nectin1 | R-LM5 | Nectin1 | express hu nectin1 | hamster kidney | [47] |
| J-PSMA | R-593 | PSMA | express hu PSMA | hamster kidney | This paper |
| RS | R-611, R-LM5 | not characterized*** | none | rabbit skin | |
| R6 | BAC-591, BAC-621, BAC-623, R-593, R-611, R-613 | not characterized*** | inducible HSV gD | rabbit skin | [43] |
| TRAMP-PSMA | R-593 | PSMA | express hu PSMA | mu prostate epithelium | [56] |
* Nectin1, HVEM/HveA; ** U251MG: for simplicity “U251” throughout the paper; *** can be inferred from range of infection.