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. 2018 Jul 4;9(7):337. doi: 10.3390/genes9070337

Figure 4.

Figure 4

miR-7 and miR-148a are primarily expressed in neuroendocrine cells and inhibit the growth of a carcinoid cell line. (A) In situ hybridization of miR-7 show robust expression of miR-7 specifically located to the neuroendocrine cells. The expression of miR-148a is also predominantly seen in the neuroendocrine cells, although to a lesser extent than miR-7. (B) qPCR of laser capture micro dissected cells confirmed that miR-7 is robustly expressed in NETs compared to normal mucosa. In contrast, the expression of miR-148a is lower in NETs than in the normal mucosa that contains endocrine cells.