Table 5.

Differentially regulated let-7 family members based on SSA treatment.

miRNA	Change	BIM-23014		BIM-23A760		BIM-53097
		FC	p-Value	FC	p-Value	FC	p-Value
let-7a	→	1.2	0.000	1.2	0.000	−1.0	NS
let-7b	↓	−1.4	0.000	−1.4	0.001	−1.0	NS
let-7c	→	−1.0	NS	1.0	NS	−1.1	NS
let-7d	→	−1.0	NS	1.0	NS	1.1	NS
let-7e	→	−1.2	NS	−1.1	NS	1.1	NS
let-7f	↑	1.8	0.002	2.1	0.000	−1.2	NS
let-7g	↑	1.7	0.001	1.9	0.000	−1.1	NS
let-7i	↑	1.3	0.000	1.4	0.000	−1.1	NS
miR-98	↑	1.8	0.004	2.2	0.000	−1.1	NS

The alteration in the expression of the let-7 family of miRNAs in NIH-H727 cells after 24 h treatment with somatostatin analogue BIM-23014, dopamine analogue BIM-53097 and the chimeric somatostatin-dopamine analogue BIM-23a760. N = 4, NS—p-value not significant.