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DSG-2 force is reduced in hyperadhesive cells. (A) MDCK cells expressing DSG-2 were treated with 10 nM of the protein kinase C (PKC) inhibitor, Gö6976, for 60 min to induce hyperadhesion. Cells stimulated with Gö6976 had increased FRET compared to control cells, indicating decreased tension. Scale bar is 20 microns. (B) Quantification of FRET differences (representative experiment of three experiments with similar results, ANOVA with Newman-Keuls post-hoc test, * p < 0.01).
