Table 2.
Adverse Event | Frequency | Duration | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Total | Escitalopram | Duloxetine | p-Value | Escitalopram | Duloxetine | p-Value | ||||||
(n = 211) | (n = 105) | (n = 106) | (n = 92) | (n = 96) | ||||||||
n | % | n | % | n | % | Mean (Days) | SD | Mean (days) | SD | |||
Nausea | 58 | 27.5 | 26 | 24.8 | 32 | 30.2 | 0.38 | 7.7 | 8.5 | 17.6 | 36.0 | 0.20 |
Headache | 53 | 25.1 | 27 | 25.7 | 26 | 24.5 | 0.84 | 20.8 | 22.7 | 12.7 | 17.4 | 0.19 |
Somnolence | 48 | 22.7 | 23 | 21.9 | 25 | 23.6 | 0.77 | 44.0 | 63.3 | 19.2 | 17.2 | 0.08 |
Sexual dysfunction | 47 | 22.3 | 23 | 21.9 | 24 | 22.6 | 0.90 | 89.0 | 93.7 | 88.5 | 70.0 | 0.98 |
Fatigue | 46 | 21.8 | 22 | 21 | 24 | 22.6 | 0.77 | 49.1 | 55.2 | 31.4 | 32.5 | 0.22 |
Insomnia | 45 | 21.3 | 20 | 19 | 25 | 23.6 | 0.42 | 71.5 | 116.4 | 37.2 | 37.3 | 0.20 |
Dry mouth | 41 | 19.4 | 16 | 15.2 | 25 | 23.6 | 0.13 | 54.4 | 62.9 | 72.3 | 73.4 | 0.43 |
Dizziness | 33 | 15.6 | 16 | 15.2 | 17 | 16 | 0.87 | 38.9 | 78.4 | 10.3 | 11.4 | 0.19 |
Diarrhea | 32 | 15.2 | 15 | 14.3 | 17 | 16 | 0.72 | 21.0 | 34.6 | 13.4 | 22.3 | 0.48 |
Constipation | 20 | 9.5 | 8 | 7.6 | 12 | 11.3 | 0.36 | 24.6 | 30.0 | 27.2 | 22.6 | 0.83 |
Anxiety | 18 | 8.5 | 8 | 7.6 | 10 | 9.4 | 0.64 | 15.8 | 18.3 | 15.4 | 16.9 | 0.97 |
Abdominal pain | 17 | 8.1 | 6 | 5.7 | 11 | 10.4 | 0.21 | 12.6 | 15.1 | 9.6 | 9.6 | 0.64 |
Yawning | 16 | 7.6 | 7 | 6.7 | 9 | 8.5 | 0.62 | 31.6 | 16.5 | 45.0 | 59.9 | 0.58 |
Appetite decreased | 16 | 7.6 | 7 | 6.7 | 9 | 8.5 | 0.62 | 20.2 | 15.6 | 50.0 | 53.2 | 0.22 |
Emotional blunting | 15 | 7.1 | 11 | 10.5 | 4 | 3.8 | 0.06 | 38.0 | 24.4 | 24.8 | 24.8 | 0.38 |
Dyspepsia | 14 | 6.6 | 6 | 5.7 | 8 | 7.5 | 0.59 | 33.8 | 42.1 | 13.8 | 11.8 | 0.34 |
Bruxism | 14 | 6.6 | 8 | 7.6 | 6 | 5.7 | 0.57 | 88.6 | 85.6 | 54.0 | 41.6 | 0.38 |
Sweating increased | 13 | 6.2 | 4 | 3.8 | 9 | 8.5 | 0.16 | 41.3 | 23.4 | 41.3 | 37.1 | 0.99 |
Jitteriness | 12 | 5.7 | 6 | 5.7 | 6 | 5.7 | 0.99 | 10.3 | 5.1 | 5.8 | 5.9 | 0.28 |
Restlessness | 11 | 5.2 | 5 | 4.8 | 6 | 5.7 | 0.77 | 18.3 | 24.5 | 19.3 | 14.7 | 0.95 |