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. 2018 Jul 16;9(7):353. doi: 10.3390/genes9070353

Figure 3.

Figure 3

Genes encoding proteins with domain architectures typical of vertebrate calcium-binding mitochondrial carrier proteins are present in the genomes of B. belcheri, B. floridae, B. lanceolatum, and A. lucayanum. (A) The B. floridae protein XP_002602990.1 is an ortholog of the calcium-binding mitochondrial carrier protein of B. belcheri (330210_PRF0), but it contains a C-terminal extension with a Peptidase_M2 domain. The transcriptome of A. lucayanum contains full-length transcripts of the gene (GESY01078193.1) encoding a protein with a domain architecture characteristic of calcium-binding mitochondrial carrier proteins. The transcriptome of B. lanceolatum contains several transcripts of the calcium-binding mitochondrial carrier protein gene and one of them, matching the C-terminal part of the protein (JT887996.1), supports the conclusion that it does not have a C-terminal Peptidase_M2 domain; (B) The corrected sequence (CMC1_BRAFL) of the calcium-binding mitochondrial carrier protein of B. floridae [21] has the same domain architecture as its orthologs of B. belcheri (CMC1_BRABE) and A. lucayanum (CMC1_ASYLU). The figure illustrates the Pfam domain architectures of the proteins and the position of protein fragments of calcium-binding mitochondrial carrier proteins. Color code for Pfam-A domains: EF-hand—green; Mito_carr—red; Peptidase_M2—blue.