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Osteolytic bone metastasis. Staining for the tartrate-resistant acid phosphatase (TRAcP) activity perfomed on a histological section of a tibia collected from a BALB-c nu/nu mouse intratibially injected with the human breast cancer cells MDA-MB-231. Purple cells represent the osteoclasts. Dashed line: tumor area. Scale: 200 µm. B: bone. OC: osteoclast. BM: bone marrow. GP: growth plate. T: tumor.
