Figure 5.

Divergence of consensus amino acids during the evolution of mammalian NQO1, AGT and GALE (uridine diphosphate glucose 4-epimerase): (A) Consensus analyses performed using a set of 50 mammalian sequences. Consensus ratio referred to the ratio between the number of sequences in the alignment containing the consensus amino acid and the number of sequences containing the amino acid found in the human protein at that position; (B,C) Divergence of the set of consensus amino acids; in panel B, divergence is shown for individual sequences, in panel C as grouped by in orders/families (mean ± standard deviation (SD)). Identity referred to pairwise identity comparison of a given sequence with the human protein as query (i.e., the human sequence equals to 1). Data for AGT and NQO1 are from [21] and reproduced with permission.