Figure 4.

Three-dimensional functional connectivity maps of the rat brain illustrating significant effects of sucrose or cocaine self-administration and Abs. A, Chamber exposure controls showed no change at 1d Abs and an increase in cortical functional connectivity at 14d Abs. B, The sucrose group largely showed increased connectivity in subcortical areas at 1d Abs. C, The cocaine group showed increased functional connectivity in subcortical areas, including thalamic, hypothalamic, and forebrain regions at 1d Abs, whereas decreases were observed at 14d Abs. All maps are composites of n = 5-8 rats and are set at a correlation threshold (edge weight) value of 0.3. Spheres represent node strength, and line thicknesses represent edge weights.