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. 2018 Jun 25;8(7):117. doi: 10.3390/brainsci8070117

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of GPi-DBS on LFP spectra. Statistical significance levels of differences were derived by comparing the DBS on-spectra to the chi-square distribution assumed for the base line (DBS-OFF) spectra (see Welch, 1967). Significant differences are marked by a ‘^#’ indicating a significance level of p < 0.05. (A–D) No spectral changes were observed in GPi_R* or GPi_L (neither at contacts 0–1 nor 2–3) during DBS of the contralateral GPi; (E,F) A slight but significant decrease was observed in the lower theta band in PPN_R* during GPI_L-DBS but no spectral change was observed in PPN_R* during GPi_R*-DBS; (G,H) DBS of either GPi_L (left) or GPi_R* (right) led to increased activity in the lower theta band in PPN_L. Abbreviations: DBS: deep brain stimulation, GPi: globus pallidus internus (_L = left, _R = right, * denotes clinically more affected side), LFP: local field potentials, PPN: pedunculopontine nucleus region (_L = left, _R = right, * denotes clinically more affected side).