Table 1.
Colorectal Cancer/High-Grade Dysplasia Features in Li–Fraumeni Patients
| Indicator | Patient 1 | Patient 2 | Patient 3 | Patient 4 | Patient 5 |
|---|---|---|---|---|---|
| Sex | M | M | M | F | F |
| Age, y | 21 | 19 | 22 | 24 | 41 |
| Mutation | P177R | I251L | Del exon 1 | R248W | Deletion exon 1 |
| FH of CRC | No | No | Yes | No | Yes |
| Additional primary | Sarc/osteo | GBM | Sarc/oligo | None | Breast/lung |
| Cancer/HGD details | |||||
| Location | Sigmoid | Sigmoid | Sigmoid | Sigmoid | Rectum |
| Type | CRC | CRC | CRC | HGD | CRC |
| Precursor lesion | TVA | TVA | TA | SSP | TA |
| Cancer size, mm | 70 | 3 | 9 | 8 | 6 |
| Invasion | LN (T3N2) | Submucosa | LN (T4N2) | None | Submucosa Transverse HGD TA 10 mm None Transverse |
Del, deletion; F, female; FH, family history; GBM, glioblastoma multiforme; LN, lymph node; M, male; osteo, osteosarcoma; oligo, oligodendroglioma; Sarc, sarcoma; TVA, tubulovillous adenoma.