. Author manuscript; available in PMC: 2019 Jun 1.

Published in final edited form as: J Acquir Immune Defic Syndr. 2018 Jun 1;78(2):169–174. doi: 10.1097/QAI.0000000000001654

TABLE 4.

Relative Change in Urine Biomarker Levels After PrEP Initiation in iPrEx-OLE

Urine Biomarker	All Participants (N = 109)		Participants With Detectable Tenofovir in Hair (N = 80)
	Percent Change^* (95% CI)	P	Percent Change^* (95% CI)	P
α1m
Unadjusted	19.7 (8.6 to 31.9)	<0.001	20.1 (6.1 to 35.9)	0.004
Adjusted for urine creatinine	20.9 (10.2 to 32.7)	<0.001	20.9 (8.0 to 35.4)	0.001
Albumin
Unadjusted	10.0 (−7.6 to 31.1)	0.28	2.9 (−16.8 to 27.1)	0.79
Adjusted for urine creatinine	5.6 (−6.8 to 19.7)	0.39	0.0 (−12.1 to 13.7)	0.99
Protein
Unadjusted	19.9 (2.4 to 40.2)	0.024	15.1 (−6.4 to 41.7)	0.18
Adjusted for urine creatinine	17.5 (7.6 to 28.3)	<0.001	15.6 (3.9 to 28.6)	0.008

Outcome is log (post/pre) biomarker; estimates are back-transformed to produce geometric % changes from robust linear regression models.