Table 3.
pEC50 and Emax values of 11 predicted FFA2 agonists in the calcium mobilization assays conducted in the βTC3 mouse β cell line are shown. Values are mean±SEM. N is the number of replicates
| pEC50 | Emax | N | |
|---|---|---|---|
| Acetate | 2.32±0.21 | 2.27±0.31 | 13 |
| Compound 1 | 6.37±1.40 | 2.00 | 3 |
| Compound 2 | 8.90±0.16 | 2.13±0.08 | 4 |
| Compound 3 | 6.05±0.37 | 2.08±0.08 | 3 |
| Compound 4 | 8.03±0.11 | 2.00 | 2 |
| Compound 5 | 4.84±0.35 | 3.02±0.88 | 2 |
| Compound 6 | 7.48 | 2.00 | 1 |
| Compound 7 | 5.32 | 2.00 | 1 |
| Compound 8 | 4.65±0.37 | 3.19±0.67 | 5 |
| Compound 9 | 6.08±2.06 | 2.37±0.37 | 2 |
| Compound 10 | 5.84±0.47 | 3.12±0.76 | 5 |
| Compound 11 | 8.97±0.62 | 2.00 | 2 |
pEC50 is the negative log of EC50 in Molar concentration and Emax is the fold increase in delta F/f values.