Table 3.
Prognosis of children diagnosed HLH with or without CNS involvement
| HLH | With/without (+/–) | Alive | Dead | OS (%) | HR | P |
|---|---|---|---|---|---|---|
| CNS involvement | + | 62 | 28 | 68.9 ± 4.9 | ||
| – | 49 | 8 | 86.0 ± 4.6 | 2.286 | 0.019 | |
| CNS symptoms | + | 22 | 15 | 59.5 ± 8.1 | ||
| – | 95 | 30 | 76.0 ± 3.8 | 2.147 | 0.047 | |
| Imaging changes | + | 56 | 20 | 73.7 ± 5.1 | ||
| – | 58 | 13 | 81.7 ± 4.6 | 0.657 | 0.244 | |
| Abnormal CSF | + | 11 | 6 | 64.7 ± 11.6 | ||
| – | 80 | 14 | 85.1 ± 3.7 | 0.255 | 0.038 |
Data are presented as mean ± SD. HLH: Hemophagocytic lymphohistiocytosis; CNS: Central nervous system; CSF: Cerebrospinal fluid; HR: Hazard ratio; OS: Overall survival; SD: Standard deviation.