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. 2018 Aug;59(8):1316–1320. doi: 10.2967/jnumed.117.205765

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FIGURE 4. — Quantification of intracellular retention of rucaparib. (A) Mean fluorescence intensities (MFI) of rucaparib and PARPi-FL over 48 h to observe clearance of rucaparib over time. (B) Normalized MFI to display on-target half-life of rucaparib measured directly via rucaparib or indirectly via PARPi-FL. Rucaparib and PARPi-FL were incubated at 0.2 μM. Decay curves were calculated with Prism using a 2-phase decay least-squares regression. Experiment was repeated 3 times with technical triplicates.