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. 2018 Mar 20;11(3):609–618. doi: 10.1016/j.tranon.2018.02.020

Figure 1.

Figure 1

Gene fusions leading to chimeric transcripts through a variety of mechanisms. Fusion genes can form at chromosomal level, where translocation, insertion, inversion, and deletion occur and produce B-A and A-B fusion mRNAs, A-B fusion mRNA, C-D fusion mRNA, and E-F fusion mRNA, respectively. Fusion transcripts can also be caused by trans-splicing (G-H fusion mRNA) or cis-splicing (I-J fusion mRNA) events at posttranscriptional level. Black blocks represent introns. Cyan block in the pre-mRNA represents intergenic region.