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FGFR3-TACC3 fusion-mediated oncogenic pathways in GBM. FGFR3-TACC3 protein can constitutively and automatically activate tyrosine kinase domain, which exerts oncogenic function weakly through PI3K/ATK, RAS/MAPK, and STAT3 signaling and may localize to mitotic spindle poles to trigger aneuploidy.
