Figure 15.
Comparison of local thyroid remnant detection by [18F]TFB- and [124I]NaI-PET/CT. Display of maximum intensity projections (outer columns) and transaxial PET and combined PET/CT slices (inner columns). (A) [124I]NaI- and [18F]TFB-PET/CT in the 56-year-old patient with DTC presented after total thyroidectomy (pT1b). [124I]NaI- and [18F]TFB-PET/CT revealed remnant benign thyroid tissue in the thyroid bed and along the thyroglossal duct with 2 foci of remnant tissue missed by [18F]TFB (arrows). No lesions suspicious for malignancy were detected. (B) Example of a 26-year-old patient after total thyroidectomy with PTC metastases exclusively detected using [18F]TFB-PET/CT. Beside a local thyroid remnant, [18F]TFB-PET/CT confirmed ultrasound results by revealing 2 cervical LNs in the left lateral compartment with focally increased uptake, consistent with metastatic disease (arrows). In contrast, [124I]NaI-PET was unremarkable for malignancy. Because of the discrepant findings, left lateral LN dissection was performed and yielded 6 additional cervical (micro-) metastases. Reproduced with permission from 22, copyright 2018 Wolters Kluwer Health, Inc.