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Summary of [18F]TFB radiosynthesis methods.
| Method | Precursor | Reaction conditions | Non-decay-corrected radiochemical yield | Overall production time | Molar activity at EOS (GBq/µmol) | Starting activity (GBq) | Reference |
|---|---|---|---|---|---|---|---|
| Isotopic exchange | NaBF4 | 120 °C, 20 min | 10% | 30 min | 1 | 12-18 | 19 |
| Radiofluorination of BF3 | Fresh BF3 | room temp, 5 s | 20.0±0.7% | 10 min | 8.84±0.56 | 40-44 | 53 |
| BF3•Et2O | 80 °C, 10 min | 13.2±5.9%a | 39 min | 5.7±3.5 | 1.5 | 54 |
adecay corrected. EOS: end of synthesis
