Table 2.

Biological pathways predicted to be regulated by the miRNAs circulating in plasma at 14 days post-injury relative to 3 days post-injury. Specific miRNAs predicted to be involved in each process, and p-value range for the association predicted, as calculated in Ingenuity pathway analysis, are indicated.

Biological functions regulated by miRNAs expressed at 14d versus 3d post-injury
Molecular and Cellular Functions	miRNAs assigned	P-value range
Cellular development	rno-let-7d-5p, rno-miR-122-5p, rno-miR-126a-5p, rno-miR-15b-5p, rno-miR-20a-5p, rno-miR-215, rno-miR-429, rno-miR-21-5p, rno-miR-223-3p, rno-miR-224-5p, rno-miR-23a-3p, rno-miR-26a-5p, rno-miR-27a-3p, rno-miR-30c-5p, rno-miR-320-3p, rno-miR-451-5p	4.55×10-2 to 1.08×10-5
Cellular growth and proliferation	rno-let-7d-5p, rno-miR-122-5p, rno-miR-126a-5p, rno-miR-15b-5p, rno-miR-20a-5p, rno-miR-21-5p, rno-miR-215, rno-miR-223-3p, rno-miR-224-5p, rno-miR-23a-3p, rno-miR-26a-5p, rno-miR-27a-3p, rno-miR-320-3p, rno-miR-429, rno-miR-451-5p	4.55×10-2 to 1.08×10-5
Cellular movement	rno-let-7d-5p, rno-miR-122-5p, rno-miR-126a-5p, rno-miR-15b-5p, rno-miR-20a-5p, rno-miR-21-5p, rno-miR-224-5p, rno-miR-23a-3p, rno-miR-26a-5p, rno-miR-27a-3p, rno-miR-320-3p, rno-miR-429, rno-miR-451-5p	4.49×10-2 to 6.20×10-7
Cell death and survival	rno-let-7d-5p, rno-miR-122-5p, rno-miR-15b-5p, rno-miR-20a-5p, rno-miR-21-5p, rno-miR-224-5p, rno-miR-30c-5p, rno-miR-320-3p, rno-miR-429, rno-miR-451-5p	4.63×10-2 to 1.16×10-4
Cell cycle	rno-let-7d-5p, rno-miR-15b-5p, rno-miR-20a-5p, rno-miR-21-5p, rno-miR-23a-3p, rno-miR-25-3p, rno-miR-26a-5p, rno-miR-27a-3p, rno-miR-451-5p	4.80×10-2 to 1.84×10-7