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(A) Schematic illustration of the assembly of oligo- or polylactide-tethered SN38 prodrugs with clinically approved amphiphilic copolymers (e.g., PEG-PLA) to form stable nanoparticles. (B) Chemical structure and synthetic scheme of oLAn-SN38 conjugate 1 (n = 8) or PLAn-SN38 conjugates 2-4 (n = 17, 36, and 71, respectively). SN38 was tethered to the carboxyl-terminated oLA or PLA through a hydrolytic ester bond linkage.
