Table 2.

Pharmacokinetic parameters of CPT-11, oLA₈-SN38-NPs, PLA₁₇-SN38-NPs, PLA₃₆-SN38-NPs, and PLA₇₁-SN38-NPs (8 mg/kg, SN38 equivalent).

PK parameter		Drug formulations
	CPT-11	oLA8-SN38-NPs	PLA17-SN38-NPs	PLA36-SN38-NPs	PLA71-SN38-NPs
t1/2α (h)	0.70	0.35	0.25	0.23	2.57
t1/2β (h)	9.06	6.32	8.31	8.70	16.73
AUC(0-t) (μg·h/mL)	67.6	179.9	395.0	1994.6	2098.8
AUC(0-inf) (μg·h/mL)	68.9	180.7	395.9	2001.1	2195.6
Cmax	23.8	74.7	74.0	178.7	155.3

AUC: area under the concentration vs time curve; t_1/2α: half-life of the distribution phase; t_1/2β: half-life of the elimination phase