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. 2018 Jun 27;8(8):2825–2832. doi: 10.1534/g3.118.200202

Figure 1.

Figure 1

Notch signaling is required for proper activity at the NMJ. (A) Time course of paralysis for lin-12(n941null) and lin-12(n137gf) mutants in response to aldicarb. Decreased LIN-12 signaling accelerates paralysis upon aldicarb treatment whereas (B) decreased GLP-1 signaling results in strong resistance to aldicarb induced paralysis. glp-1(q231lf) is rescued by transgenic glp-1 expression. (C) Partial loss of the CSL transcription factor LAG-1, lag-1(om13lf), confers hypersensitivity to 1mM aldicarb. (at least three independent trials for each experiment, n > 30 for all genotypes, error bars represent SEM *: log-rank p-value < 0.05, **: log-rank p-value < 0.01, ***: log-rank p-value < 0.001, ns: no significant difference. For (B) and (C) all animals were reared at 15°C and switched to the restrictive temperature of 25°C in the first larval stage.)